Ultrafine megestrol acetate particles prepared by subcritical water method

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Journal of Beijing University of Chemical Technology ›› 2013, Vol. 40 ›› Issue (s1) : 10-14.

材料科学与工程

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The micronization of megestrol acetate (MA) was obtained by using the technology of subcritical water (SBCW) in this study. The influences of the experimental parameters, such as temperature difference, volume ratio of subcritical water and deionized water, stirring condition, surfactant concentration were studied. The optimized technological conditions were as follow: the temperature of subcritical water and deionized water was 0℃, 170℃ respectively, the volume ratio of 13:6, the proper stirring speed and time of the receiver (deionized water) were 1000r/min and 1h, the surfactant mass fraction of polyvinylpyrrolidone (PVP) was 01%. The diameter of the particles prepared in the optimal conditions was in a range of 100 to 500nm. Infrared spectra of raw materials and prepared samples showed that chemical construction did not occur in the experiment. Results of dissolution rate tests showed that the dissolution rate of MA particles was enhanced significantly, and 86.7% drug dissolution was achieved within 30min.

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Ultrafine megestrol acetate particles prepared by subcritical water method[J]. Journal of Beijing University of Chemical Technology, 2013, 40(s1): 10-14

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2013-04-02	1900-01-01	2013-12-20
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2013-12-20

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