Properties of hyaluronic acid cross-linked by γ-irradiation

Liu He;Zhang LiYe

Journal of Beijing University of Chemical Technology ›› 2011, Vol. 38 ›› Issue (6) : 49-53.

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Journal of Beijing University of Chemical Technology ›› 2011, Vol. 38 ›› Issue (6) : 49-53.
材料科学与工程

Properties of hyaluronic acid cross-linked by γ-irradiation

  • Liu He;Zhang LiYe
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Abstract

Glycidyl methacrylate (GMA) has been grafted onto hyaluronic acid (HA) to form GMAHA conjugates. After treating the solution of GMAHA derivatives with60Co-γ irradiation, a cross-linked HA gel was obtained. The value of the storage modulus (G′) of the HA gel was larger than the value of the loss modulus (G″) and the slopes approached zero. The cross-linked HA gel can be characterized as a strong hydrogel. The HA gel absorbed 20-50 times its own weight of water. For a fixed molecular weight of HA, the water uptake capability of the cross-linked HA gel decreased as the concentration of GMAHA and γ-ray dosage increased within a certain range. The cross-linked HA gel is a degradable material. The antioxidative and anti-enzymolysis capabilities of the cross-linked HA gel were considerably superior to those of HA itself. When the preparation conditions were varied, it was found that the pH and the ambient temperature were the main factors influencing the anti-oxidative and anti-enzymolysis capabilities of the resulting cross-linked HA gel.

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Liu He;Zhang LiYe. Properties of hyaluronic acid cross-linked by γ-irradiation[J]. Journal of Beijing University of Chemical Technology, 2011, 38(6): 49-53

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