Degradation characteristics of hyaluronic acid crosslinked by irradiation

ZHANG Li;ZHANG LiYe

Journal of Beijing University of Chemical Technology ›› 2009, Vol. 36 ›› Issue (s1) : 46-49.

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Journal of Beijing University of Chemical Technology ›› 2009, Vol. 36 ›› Issue (s1) : 46-49.
材料科学与工程

Degradation characteristics of hyaluronic acid crosslinked by irradiation

  • ZHANG Li;ZHANG LiYe
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Abstract

GM grafting method was adopted to prepare HA derivatives (GMHA) and get HA gels after exposing it under γ-ray. It was shown in the spectrophotometer test that HA gel was a degradable material. The stability of the gel was changed by the preparated condition and the environmental condition: the 700000Da molecular weight was more stable than 100000Da molecular weight. The 1kGy of irradite dosage was less stable than 5kGy for the HA gels. The HA gel was much easier to degrate when pH at 7, and the low temperature was good for the gel to keep stable, it degrated rapidly at 50℃.

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ZHANG Li;ZHANG LiYe. Degradation characteristics of hyaluronic acid crosslinked by irradiation[J]. Journal of Beijing University of Chemical Technology, 2009, 36(s1): 46-49

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