Preparation and characterization of doxorubicin-loaded microcapsules

RAO Jun; TAO Xia; CHEN JianFeng

Journal of Beijing University of Chemical Technology ›› 2008, Vol. 35 ›› Issue (4) : 69-72.

PDF(1295 KB)
Welcome to Journal of Beijing University of Chemical Technology, Today is July 17, 2025
Email Alert  RSS
PDF(1295 KB)
Journal of Beijing University of Chemical Technology ›› 2008, Vol. 35 ›› Issue (4) : 69-72.
生物技术和环境工程

Preparation and characterization of doxorubicin-loaded microcapsules

  • RAO Jun; TAO Xia; CHEN JianFeng
Author information +
History +

Abstract

Doxorubicin (DOX)-loaded poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) microcapsules have been prepared by a double emulsion technique and characterized by dynamic laser light scattering, scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). SEM showed that the microcapsules had a size of ca. 900nm and smooth spherical surfaces. CLSM images directly verified that DOX was encapsulated into the microcapsules. The entrapment ratio of DOX in the capsules amounted to 35.7%. The effects of varying the preparation conditions on the microcapsule size and DOX encapsulation efficiency were also investigated. Drug release studies in a physiological environment indicated that the controlled release of DOX from the microcapsules could be sustained for over 10?days.

Cite this article

Download Citations
RAO Jun; TAO Xia; CHEN JianFeng. Preparation and characterization of doxorubicin-loaded microcapsules[J]. Journal of Beijing University of Chemical Technology, 2008, 35(4): 69-72

References

[1]Ventatraman S S, Pan J, Feng M, et al. Micelle-like nanoparticles of PLA-PEG-PLA triblock copolymer as chemotherapeutic carrier[J]. International Journal of Pharmaceutics, 2005, 298(1): 219-232. 
[2]Ruan G, Feng S S. Preparation and characterization of poly (lactic acid)-poly (ethylene glycol)-poly (lactic
acid) ( PLA-PEG-PLA)microspheres forcontrolled release of paclitaxel[J]. Biomaterials, 2003, 24(27):5037-5044. 
[3]Li Xiaohong, Deng Xiaomo, Yuan Minglong, et al. In vitro degradation and release profiles of poly-dl-lactide
poly(ethylene glycol) microspheres with entrapped proteins[J]. Journal of Applied Polymer Science, 2000, 78: 140-148. 
[4]杨远,贾文祥,祁欣,等. 可生物降解材料作为基因载体的研究[J]. 生物医学工程学杂志,2006,23(3):573-577. 
[5]牛文强,傅国旗,吴俊丽,等. PLA/PEG/PLA三嵌段共聚物载药纳米胶囊的制备及表征[J]. 高等学校化学学报,2005,26(7):1369
-1371. 
[6]Dos Santos R A, Takahashi C S. Anticlastogenic and antigenotoxic effects of selenomethionine on doxorubicininduced
damage in vitro in human lymphocytes[J]. Food and Chemical Toxicology, 2008, 46(2): 671-677. 
[7]Omelyanenko V, Kope ˇková P, Gentry C, et al. Targetable HPMA copolymer-adriamycin
conjugates: recognition, internalization and subcellular fate[J]. Journal of Controlled Release, 1998, 53(1-3): 25-37. 
[8]林本兰,沈晓东,崔升,等. 磁性纳米粒阿霉素微球制备的初探[J]. 中国医院药学杂志, 2005, 25(5): 424-426. 
[9]李范珠,胡晋. 阿霉素纳米囊的制备工艺及其毒性试验[J]. 中国现代医用药学杂志,2006, 23(6): 474-477. 
[10]Yeo Y, Back N, Park K. Microencapsulation method for delivery of protein drug[J]. Biotechnol Bioprocess
Eng, 2001, 6:213-230. 
[11]Jain R A. The manufacturing techniques of various drug loaded biodegradable PLGA devices[J].
Biomaterials,2000,21(23):2475-2490. 
[12]Meng Fentao, Ma Guanghui, Qiu Wei, et al. W/O/W double emulsion technique using ethyl acetate as organic
solvent:effects of its diffusion rate on the characteristics of microparticles[J]. Journal of controlled release,2003,91(3):407-416. 
[13]赵瑞玲,谢茵,丁红. 紫外分光光度法测定阿霉素聚乳酸微球含量[J]. 山西医科大学学报,2003, 34(2): 166-167.

PDF(1295 KB)

4219

Accesses

0

Citation

Detail

Sections
Recommended

/