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Preparation and characterization of doxorubicin-loaded microcapsules
RAO Jun; TAO Xia; CHEN JianFeng
Journal of Beijing University of Chemical Technology ›› 2008, Vol. 35 ›› Issue (4) : 69-72.
PDF(1295 KB)
PDF(1295 KB)
Preparation and characterization of doxorubicin-loaded microcapsules
Doxorubicin (DOX)-loaded poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) microcapsules have been prepared by a double emulsion technique and characterized by dynamic laser light scattering, scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). SEM showed that the microcapsules had a size of ca. 900nm and smooth spherical surfaces. CLSM images directly verified that DOX was encapsulated into the microcapsules. The entrapment ratio of DOX in the capsules amounted to 35.7%. The effects of varying the preparation conditions on the microcapsule size and DOX encapsulation efficiency were also investigated. Drug release studies in a physiological environment indicated that the controlled release of DOX from the microcapsules could be sustained for over 10?days.
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