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Synthesis of a novel amine-terminated cyclotriphosphazene derivative
GUAN LiJuan;ZHANG Teng;DU TanXin;JIN RiGuang
Journal of Beijing University of Chemical Technology ›› 2008, Vol. 35 ›› Issue (1) : 11-14.
PDF(858 KB)
PDF(858 KB)
Synthesis of a novel amine-terminated cyclotriphosphazene derivative
GUAN LiJuan;ZHANG Teng;DU TanXin;JIN RiGuang
A glycine ethyl ester of cyclotriphosphazene has been synthesized from hexachlorocyclotriphosphazene as precursor. Subsequent reaction of the glycine ethyl ester cyclotriphosphazene with ethylenediamine in an "amino-ester exchange reaction" afforded an amine terminated cyclotriphosphazene derivative. This method has the advantages of convenient manipulation, mild reaction conditions and high yield (95%). All synthesized compounds were characterized by IR, 1H-NMR and mass spectroscopies. The influence of varying the synthesis conditions, such as reaction temperature, reaction time and ratio of reactants was investigated.
［1李时珍, 徐伟箭, 黄远驹. 六(氨基苯氧)环三磷腈的合成［J］. 科技与
经济, 2006, 19: 124-125.
［2］Cil E, Arslan M, Grgülü A O. Synthesis and characteri~zatio
n of benzyl and benzoyl substituted oximephosphazenes［J］. Polyhedron, 2006
, 25: 3526-3532.
[3］Yuan Weizhong, Zhu Lu, Huang Xiaobin, et al. Synthesis, characterizat
ion and degradation of hexaarmed starshaped poly(Llactide)s and poly(D,L
lactide)s initiated with hydroxylterminated cyclotriphosphazene［J］. Polymer
Degradation and Stability, 2005, 87: 503-509.
［4］Inoue K, Horibe S, Fukae M, et al. Synthesis and conformation of star
shaped poly(γbenzylLglutamate)s on a cyclotriphosphazene core［J］.
Macromolecular Bioscience, 2003 (3): 26-33.
［5］Allcock H R, Kwon S. Covalent linkage of proteins to surfacemodifie
d poly(organophosphazenes) immobilization of glucose6phosphate dehydrogena
se and trypsin［J］. Macromolecules, 1986, 19：1502-1508.
［6］魏浩, 王玲, 韦萍, 等. 保护赖氨酸的制备工艺［J］. 南京工业大学学
报, 2003, 25(4): 45-48.
［7］Esfand R, Tomalia D A. Poly(amidoamine) (PAMAM) dendrimers: From biomimicry to drug delivery and biomedical applications［J］. Drug Discovery Today,
2001, 6(8): 427-436.
［8］Svenson S, Tomalia D A. Dendrimers in biomedical applicationsreflec
tions on the field［J］. Advanced Drug Delivery Reviews, 2005, 57:2106-2129.
［9］孙德, 李然, 张龙. 六氯环三磷腈的合成及分离［J］. 化学工程师, 2006, 127(4): 30-32.〖ZK)〗
［10］Singh A, Krogman N R, Sethuraman S, et al. Effect of side gr
oup chemistry on the properties of biodegradable Lalanine cosubstituted polyph
osphazenes［J］. Biomacromolecules, 2006, 7: 914-918.
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