QSAR of d4T nucleoside analogues against HIV-1 activity
LI Jiang bo;XIE Hua qing;ZHANG Jing chang;CAO Wei liang
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Faculty of Science; Beijing University of Chemical Technology; Beijing; China
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History+
Received
Revised
Published
2000-06-26
1900-01-01
2001-03-10
Issue Date
2001-03-10
Abstract
In this paper, quantitative structure activity relationships (QSAR) of 20compounds which belong to nucleoside analogue were studied by using the method of molecular connectivity index, and one equation of QSAR was established ( R=0.94). The model revealed that the anti-HIV-1 activity was significantly correlated with the n M,lg P , (lg P )2 and 6χvP. As known from the equation, the molecular connectivity index 6χvP played more important role than that of the electronic parameter σ.
LI Jiang bo;XIE Hua qing;ZHANG Jing chang;CAO Wei liang .
QSAR of d4T nucleoside analogues against HIV-1 activity[J]. Journal of Beijing University of Chemical Technology, 2001, 28(1): 79-80
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