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十八胺/羟丙基-β-环糊精包合物的制备与分析
Preparation and analysis of the inclusion complex of octadecylamine with hydroxylpropyl-β-cyclodextrin
以羟丙基-β-环糊精（HP-β-CD）为主体，十八胺（ODA）为客体，采用研磨法制备了具有超分子结构的ODA/HP-β-CD包合物。考察了研磨时间、主客体物质的量比及包合温度对包合率的影响，确定了包合物的最佳制备工艺：研磨时间15min,主客体物质的量比2:1,热处理温度75℃。1H NMR和XRD衍射结果表明，ODA成功包合入HP-β-CD空腔中。通过相溶解度法研究了HP-β-CD在水中对ODA的增溶作用，结果表明HP-β-CD在水中对ODA增溶效果显著；经计算确定其包合常数为7877.69L/mol，形成的包合物结构稳定。
An inclusion complex with octadecylamine (ODA) as guest and hydroxylpropyl-β-cyclodextrin (HP-β-CD) as host has been prepared by a grinding method. The influence of varying the grinding time, the molar ratio of host:guest and the temperature on the inclusion ratio was investigated. The optimum preparation conditions were as follows: a molar ratio of host∶guest of 2∶1, a grinding time of 20min, and a heating temperature of 75℃. 1H-NMR spectroscopy and XRD confirmed that the ODA was successfully embedded in the cavity of HP-β-CD. The phase solubility method was used to study the influence of HP-β-CD on the solubility of ODA in water. It was found that HP-β-CD significantly increased the solubility of ODA in water. The inclusion constant was 7877.69L/mol, which indicates that the inclusion complex was relatively stable.
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