PDF(2099 KB)
微通道反应器内纳米头孢呋辛酯制备工艺优化
张乾霞; 娄金婷; 周月; 段永鸿; 王洁欣*
北京化工大学学报（自然科学版） ›› 2011, Vol. 38 ›› Issue (1) : 15-20.
PDF(2099 KB)
PDF(2099 KB)
微通道反应器内纳米头孢呋辛酯制备工艺优化
Optimization of the preparation of cefuroxime axetil nanoparticles in a microchannel by orthogonal tests
［1］平其能. 纳米药物和纳米载体系统［J］. 中国新药杂志， 2002, 11(1): 42-46.
Ping Q N. Nano-medicines and nano-carrier system［J］. Chinese Journal of New
Drugs， 2002, 11(1): 42-46. (in Chinese)
［2］Won D, Kim M, Lee S, et al. Improved physicochemical characteristics of felodipine solid dispersion particles by supercritical antisolvent precipitation process［J］. International Journal of Pharmaceutics，2005, 301(1/2): 199-208.［3］ZhongJ, Shen Z G, Yang Y, et al. Preparation and characterization of uniform nanosized cephradine by combination of reactive precipitation and liquid anti-solvent precipitation under high gravity environment［J］. International Journal of Pharmaceutics, 2005, 301(1/2): 286-293.
［4］Kim J, Kim M, Park H, et al. Physicochemical properties and oral bioa
vailability of amorphous atorvastatin hemi-calcium using spray-drying and SAS
process［J］. International Journal of Pharmaceutics, 2008, 359(1/2): 211-219.［5］WangZ, Chen J F, Le Y, et al. Preparation of ultrafine beclomethasone dipropionate drug powder by antisolvent precipitation［J］. Industrial & Engineering Chemistry Research， 2007, 46(14): 4839-4845.
［6］Wagner J, Khler J M. Continuous synthesis of gold nanoparticles in a microreactor［J］. Nano Letters， 2005, 4(5): 685-691.
［7］国家药典委员会. 中华人民共和国药典(二部)［M］. 北京： 化学工业出版社, 2005: 291. Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China: Chemical Industry Press, 2005: 291. (in Chinese)
［8］ZhangJ Y, Shen Z G, Zhong J, et al. Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfacta
nts［J］. International Journal of Pharmaceutics, 2006, 323(1): 153-160.
［9］ViolantoM R, Fishcher H W. Method formaking uniformly sized particles from water-insoluble organic compounds: US， 4826689［P］. 1989-05-02.
［10］马静, 王玉红, 王丹梅, 等. 旋转填充床中反溶剂重结晶法制备超细硫酸沙丁胺醇实验研究［J］. 材料科学与工程学报， 2004, 22(1)： 74-77.
Ma J, Wang Y H, Wang D M, et al. Preparation of particles of ultra-fine salbuta
mol sulfate by anti-solvent re-crystallization in a rotating packed bed［J］.
Journal of Matererial Science Engineering, 2004, 22(1): 74-77. (in Chinese)
［11］ZhaoH, Wang J X, Wang Q A, et al. Controlled liquid antisolvent precipitation of hydrophobic pharmaceutical nanoparticles in a microchannel reactor［J］. Industrial & Engineering Chemistry Research, 2007, 46(24): 8229-8235.
［12］KarnikR, Gu F, Basto P, et al. Microfluidic platform for controlled synthesis of polymeric nanoparticles［J］. Nano Letters, 2008, 8(9): 2906-2912.
［13］Kim M, Jin S, Kim J, et al. Preparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical
antisolvent (SAS) process［J］. European Journal of Pharmaceutics and Biopharm
aceutics, 2008, 69(2): 454-465.
［14］龙涛， 田熙科， 杨超， 等. 超细阿奇霉素的制备及表征［J］. 化工进展， 2005， 24(7)： 763-766.
Long T, Tian X K, Yang C, et al. Preparation and characterization of ultra-fine
Azihromycin［J］. Chemical Industry and Engineering Progress， 2005， 24(7)： 763-766. (in Chinese)
/
| 〈 |
|
〉 |
