开发了填充床式固定化酶反应器合成高档化妆品原料棕榈酸异辛酯的生产工艺，以棕榈酸，
异辛醇为原料，使用实验室自制的固定化假丝酵母脂肪酶99-125为催化剂。并对反应器的
固定化酶用量，底物浓度，循环流速，填充柱径高比等操作参数以及稳定性进行了研究，反
应12h最终的酯化率可达97%，固定化酶使用31批以后，12h酯化率仍然可以达到93%。

Iso-octyl palmitate (IOP) has been synthesized from palmitic acid and 2-ethyl hexanol in a packedbed reactor with immobilized lipase Candida sp. 99125 as the catalyst. The effects of varying the dosage of immobilized lipase, the concentration of raw materials, the velocity of reactant flow, and the diameter to height ratio of the packed bed on the reaction were investigated. Under optimum conditions, the maximum esterification extent reached 97%. The stability of the immobilized lipase was found to be excellent, with the extent of esterification remaining above 93% when the material was reused in 31 batch cycles. 