新型“一锅法”合成异噁唑及吡唑类化合物

周雷;程斌*

北京化工大学学报(自然科学版) ›› 2012, Vol. 39 ›› Issue (6) : 47-51.

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北京化工大学学报(自然科学版) ›› 2012, Vol. 39 ›› Issue (6) : 47-51.
材料科学与工程

新型“一锅法”合成异噁唑及吡唑类化合物

  • 周雷;程斌*
作者信息 +

A novel “one-pot” method for the preparation of pyrazoles and isoxazoles

  • ZHOU Lei;CHENG Bin
Author information +
文章历史 +

摘要

采用新型“一锅法”,即所有参与反应的原料放在“一锅”中,通过调节反应体系的pH值和温度来控制引发下一步反应,合成了异噁唑、吡唑类化合物,得到了与传统“一锅法”相近的产率。并研究了取代基和溶剂对反应的影响,证明新型“一锅法”有广谱的适用性。

Abstract

A novel “one-pot” method for preparation of isoxazoles and pyrazoles, with same yield as the traditional “one-pot” method, have been developed. In contrast to the traditional “one-pot” method, all the reagents were put together during the first reaction, and the second reaction was triggered by changing the pH or temperature of the reaction solution. Step-by-step addition of reagents is thus not needed. The results with a wide range of substituents demonstrated that the method can tolerate many different functional groups.

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周雷;程斌*. 新型“一锅法”合成异噁唑及吡唑类化合物[J]. 北京化工大学学报(自然科学版), 2012, 39(6): 47-51
ZHOU Lei;CHENG Bin. A novel “one-pot” method for the preparation of pyrazoles and isoxazoles[J]. Journal of Beijing University of Chemical Technology, 2012, 39(6): 47-51

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