以离子交换树脂为催化剂，苯酚与乙二醛为原料，合成了四酚基乙烷。采用高效液相色谱仪与质谱仪联用分析四酚基乙烷含量，建立了分析和计算四酚基乙烷产率的方法，研究了合成反应条件（酚醛比、反应时间）对四酚基乙烷产率的影响。结果表明，增加苯酚的用量，四酚基乙烷产率先提高后下降，当苯酚与乙二醛物质的量比为15∶1时产率达到31.14%（反应时间8h）；增加反应时间到32h，四酚基乙烷产率提高到78.80%，24h后产率提高变缓。

The condensation reaction of phenol and glyoxal has been carried out using isopropyl alcohol as solvent in the presence of No.732 cationic exchange resin as catalyst. The factors affecting the yield of tetraphenol ethane were studied, and an effective methodology to determine the yield was developed using a combination of high performance liquid chromatography and mass spectrometry. With this method, the effect of varying the ratio of phenol and glyoxal and the reaction time on the ultimate yield were clarified. The results showed that when the concentration of phenol was increased, the yield of tetraphenol ethane initially increased and then decreased. The maximum yield of 31.14% (at a reaction time of 8.h) was reached when the amount of substance ratio of phenol and glyoxal was 15∶1 The yield increased gradually with increasing reaction time, and reached 78.80% after 32h.