智能海藻酸钙/PNIPAAm互穿网络水凝胶微囊制备研究

许立新1;王秀芬1*;甘 霓1;张立群2;

北京化工大学学报(自然科学版) ›› 2005, Vol. 32 ›› Issue (1) : 55-58.

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北京化工大学学报(自然科学版) ›› 2005, Vol. 32 ›› Issue (1) : 55-58.
研究论文

智能海藻酸钙/PNIPAAm互穿网络水凝胶微囊制备研究

  • 许立新;王秀芬*;甘 霓;张立群;
作者信息 +

Preparation of intelligent calcium alginate/PNIPAAm interpenetrating network hydrogel beads

  • XU Lixin1;WANG Xiufen1*;GAN Ni1; ZHANG Liqun2;
Author information +
文章历史 +

摘要

以海藻酸钙凝胶为聚合模板,过硫酸铵/偏重亚硫酸钠氧化还原引发剂体系、自由基水溶液法聚合制备了温度敏感和pH敏感的海藻酸钙/聚N异丙基丙烯酰胺(CA/PNIPAAm)互穿网络水凝胶微囊。并研究了引发剂用量、单体量、单体/海藻酸钠配比、缓冲液pH值等因素对该互穿智能水凝胶温度敏感和pH敏感性的影响。结果表明:该互穿凝胶微囊对pH/温度具有敏感溶胀性,可望作为口服药物缓释制剂的载体。

Abstract

A thermo and pHsensitive interpenetrating network hydrogels beads were prepared with both calcium alginate and PNIPAAm hydrogels which were synthesized by freeradical aqueous solution polymerization using APS(ammonium persulphate)/Na2S2O5(Sodium pyrosulfite) as redox initiators in a simultaneous interpenetrating network process. The effects of the initiator concentration,monomer concentration, NIPAAm/alginate ratio, the solution pH values on the gel swelling performance in different temperatures and pH solutions were discussed. Results show that the IPN hydrogel beads exhibit thermo and pHsensitive swelling ratio characteristics. Therefore, the IPN hydrogels may be useful in the field of controlled drug delivery.

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导出引用
许立新1;王秀芬1*;甘 霓1;张立群2;. 智能海藻酸钙/PNIPAAm互穿网络水凝胶微囊制备研究[J]. 北京化工大学学报(自然科学版), 2005, 32(1): 55-58
XU Lixin1;WANG Xiufen1*;GAN Ni1; ZHANG Liqun2;. Preparation of intelligent calcium alginate/PNIPAAm interpenetrating network hydrogel beads[J]. Journal of Beijing University of Chemical Technology, 2005, 32(1): 55-58

参考文献

[1 ]  Shunsuke Hirotsu , Yoshitsugu Hirokawa , Toylchi Tanaka. Volume2phase transitions of ionized N-isopropylaceylamide gels [ J ] . J Chem Phys , 1987 , 87
(2) :1392 - 1395
[2 ]  吴 奇, 汪晓辉, 高 均. 激光光散射研究聚(N-异丙基丙烯酰胺) 单链及其智能凝胶微囊在水中的相变(下) [J ] . 高分子通报,1998 (4) :1 - 9

[3 ]  Mitsuhiro shibayama , Kazuki Kawakubo , Tomohisa Norisuye. Comparison of the experimental and theoretical structure factors of temperature polymergels [ J ] .Macromolecules , 1998 , 31 (5) :1608 - 1614
[4 ]  Marchetti M , Prager S , Cussler E L. Thermodynamic predictions of volume changes in temperature2sensitive gels 2 : experiments[J ] . Macromolecules , 1990 ,23(14) :3445 - 3450
[5 ]  Francoise M Winnik. Fluorescence studies of aqueous solutions of poly(N2isopropylacrylamide) below and above their LCST[J ] . Macromolecules ,1990 ,23(1) :233 - 242
[6 ]  Fujishige S , Kubota K, Ando I. Phase transition of aqueous solutions of poly2 (N2isopropylacrylamide) and poly-( N-isopropylmethacrylamide) [ J ] . J Phys Chem ,1989 ,93 (8) :3311 - 3313
[7 ]  Liu Wenguang , Zhang Bingqi , William W Lu , et al . A rapid temperature-responsive sol-gel reversible poly (N-isopropylacrylamide )-g-methylcellulose copolymer hydrogel[J ] .Biomaterials , 2004 ,25 : 3005 - 3012
[8 ]  Jae Ho Cho , Su-Hyang Kim , Ki Dong Park , et al . Chondrogenic differentiation of human mesenchymal stem cells using a thermosensitive poly(N-isopropylacrylamide) and water2soluble chitosan copolymer [J ] . Biomaterials ,2004 , 25 :5743 - 5751
[9 ]  卓仁禧,张先正. 温度及pH 敏感聚(丙烯酸) / 聚(N 异丙基丙烯酰胺) 互穿聚合物网络水凝胶的合成及性能研究[J ] . 高分子学报, 1998 (1) : 39 - 42
[10 ]  Tatsuya Motonage ,Mitsuhiro Shibayama. Studies on pH and temperature dependence of the dynamics and heterogeneities in poly (N2isopropylacrylamide-co-sodium acrylate) gels[J ] . Polymer ,2001 ,42(21) :8925 - 8934
[11 ]  Olivier Meyer , Demetrios Papahadjopoulos , Jean-Christophe Leroux. Copolymers of N-isopropylacrylamide can trigger pH sensitivity to stable
liposoomes[J ] . FEBS Letters , 1998 ,421 : 61 - 64
[12 ]  记明候. 海藻化学[M] . 北京:科学出版社,1997 ,268
[13 ]  Hee Kyung J u ,So Yeon Kim , Seon Jeong kim , et al . pH/ Temperature-responsive semi-IPN hydrogels composed of alginate and poly (N-isopropylacrylamide)[J ] . Journal of Applied Polymer Science , 2002 , 83 :
1128 - 1139

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